neurontin and hyponatremia does gabapentin cause memory loss in the elderly

This case can help clinicians diagnose and treat new-onset hyponatremia in patients who recently initiated pregabalin therapy. Keywords: Drug associated syndrome of inappropriate antidiuretic hormone secretion, Hyponatremia, Pregabalin. Introduction. Hyponatremia is the most frequent electrolyte disturbance among hospitalized patients1,2). Hyponatremia is an adverse effect of some antiepileptic drugs (AEDs) and has been especially reported under oxcarbazepine (OXC) and carbamazepine (CBZ) (Dong et al., 2005; Lu and Wang, 2017). Drug-induced hyponatremia caused by renal water retention is mainly due to syndrome of inappropriate antidiuresis (SIAD). SIAD can be grouped into syndrome of inappropriate antidiuretic hormone secretion (SIADH) and nephrogenic syndrome of inappropriate antidiuresis (NSIAD). The incidence of hyponatremia caused by SSRIs varies widely from 0.5% to 32%. In the majority of cases, hyponatremia occurs within the first few weeks of the onset of therapy, whereas the normonatremia is achieved within 2 weeks after drug withdrawal. Drug-induced hyponatremia caused by renal water retention is mainly due to syndrome of inappropriate antidiuresis (SIAD). SIAD can be grouped into syndrome of inappropriate antidiuretic hormone secretion (SIADH) and nephrogenic syndrome of inappropriate antidiuresis (NSIAD). The former is characterized by uncontrolled hypersecretion of arginine vasopressin (AVP), and the latter is produced by As shown in evidence from small studies and case reports, drugs may cause hyponatremia by affecting sodium homeostasis and water ho-meostasis. Clinical information about the inci-dence and pathophysiological process of hypona-tremia of the most commonly offending agents is presented first (Table 1). Patient Experiences with Gabapentin and Hyponatremia. Learning how gabapentin can cause hyponatremia is key. Hearing from those who have been affected gives us deep insights. Their stories help others understand what they might face. Personal Stories and Case Studies. Many patients have talked about their time with gabapentin and hyponatremia. Expert opinion: Carbamazepine and oxcarbazepine are the most common AEDs which induce hyponatremia in patients with epilepsy. Recently, other AEDs, such as eslicarbazepine, sodium valproate, lamotrigine, levetiracetam and gabapentin have also been reported to cause hyponatremia. We examined the 30-day risk of hospitalization with hyponatremia associated with initiating carbamazepine, valproic acid, phenytoin, or topiramate in the outpatient setting relative to no antiepileptic use. Hyponatremia is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Ondansetron, and have Stress and anxiety. In this review, we will discuss common ASMs associated with hyponatremia, the mechanism of action of various ASMs, clinical symptoms, the presentation of hyponatremia, and treatment strategies for hyponatremia in patients using ASMs. The most frequent electrolyte disorder in hospitalized patients is hyponatremia [1]. The clinical spectrum in hyponatremia ranges from mild, non-specific symptoms such as fatigue, headache, and gait instability to life-threatening symptoms such as seizures, coma and ultimately death, secondary to brain oedema [2,3]. Pharmaceutical drugs, e.g., thiazide diuretics, antidepressants and Background. Gabapentin binds to the alpha-2-delta subunit of presynaptic voltage-gated calcium channels and is used for a wide variety of indications both Food and Drug Administration approved and off-label. 1-3 It is approved by the Food and Drug Administration to treat postherpetic neuralgia and epilepsy 4 with common off-label indications including fibromyalgia, anxiety, mood disorders, and Signs of Gabapentin-Induced Hyponatremia. Gabapentin-induced hyponatremia is a serious condition that can have potentially dangerous consequences if left untreated. It is essential to recognize the signs and symptoms of this condition to ensure prompt medical intervention. Some common signs of gabapentin-induced hyponatremia include: 1. Nausea The corresponding association for phenytoin and valproate was moderate. The risk for hyponatremia was lower during ongoing treatment. Lamotrigine and gabapentin had the lowest risk both during initiation and ongoing treatment and may be advantageous in patients at risk of developing hyponatremia. In the excellent review of drug-induced hyponatremia, Liamis et al1 gave clinical information about the incidence of hyponatremia associated with specific drug treatment and discussed the underlying pathophysiological mechanisms. Hyponatremia induced by antiepileptic drugs is common, but detailed evidence is lacking. This can be problematic for the treating neurologist confronted with a patient with severe hyponatremia in need of an alternative drug. The incidence of hyponatremia in patients taking paroxetine is 3.5/1,000/year. 2 Although about 50 case reports of SSRI-induced hyponatremia have appeared in the literature so far, 3 fatal hyponatremia due to psychotropic drug polypharmacy has been reported only once. 1 Listed below are some drugs that may cause hyponatraemia (serum sodium concentration below 135 mmol/L) However, these reports were based on only 1–4 patients with severe hyponatremia, so the actual incidence of this problem is unknown. According to a population-based case-control study, use of CBZ, phenytoin (PHT), VPA, LTG, LEV, or gabapentin increases the risk of hospitalization for hyponatremia [17]. However, this study was based on a

neurontin and hyponatremia does gabapentin cause memory loss in the elderly
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