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Issue: Most patients with a bipolar spectrum disorder are treated with 2 or more drugs in combinations that are sometimes rational and evidence-based and sometimes not. a hot topic, with many new agents now available and many new combinations being touted. Mood stabilizers are usually the first choice to treat bipolar disorder. Gabapentin (Fanatrex, Gabarone, Horizant, or Neurontin) Topiramate (Topamax or Topiragen) Tegretol, Topamax, Neurontin, Lamictal, Zonegran, and Depakote are also used for seizures. Depakote may best help rapid cycling and mixed mania/depression. It also helps prevent migraines. Lamotrigine and Lithium best treat Bipolar depressed phase. Lamotrigine may help non-Bipolar depression too. Gabapentin (Neurontin) Topiramate (Topamax) Oxcarbazepine (Trileptal) Lamotrigine (Lamictal) Some of the most used antipsychotics include: Quetiapine (Seroquel) Clozapine (Clozaril) Risperidone Topiramate has one huge advantage over many other psychotropics: it causes weight loss -not gain. While gabapentin caused an average gain of 2.2 kg during randomized trials (nearly as much as olanzapine’s 2.4 kg and worse than quetiapine’s 1.1 kg), topiramate caused an average loss of 3.8 kg. 3 Bipolar disorder (BD) is a complex, chronic and often severe mood disorder which presents significant management challenges (McIntyre et al., 2020).There are many pharmacological and non-pharmacological approaches approved or under investigation to treat acute mania, acute bipolar depression, as well as maintenance treatment to prevent mood episodes (Yatham et al., 2018). Efficacy for bipolar disorder patients is not yet established for gabapentin monotherapy, but the combination of valproate and gabapentin may be a reasonable treatment approach for patients with refractory illness. This review of the literature synthesizes the available data on ten AEDs—valproate, carbamazepine, oxcarbazepine, phenytoin, lamotrigine, topiramate, levetiracetam, zonisamide, gabapentin and tiagabine—in an attempt to assess evidence for the efficacy of AEDs in the treatment of aggression in pediatric populations. Lurasidone and lamotrigine are either untested (lurasidone) or ineffective (lamotrigine) in mania, but they are essential tools for bipolar depression. Lithium stands out for its preventative effects in bipolar disorder, but it also has important benefits outside of the manic-depressive symptom lists. Antipsychotic Bipolar Medications . Antipsychotic medications are often prescribed for those with bipolar disorder, especially Bipolar I, where delusions and hallucinations are present. Antipsychotic medications can help manage psychotic symptoms associated with bipolar illness, and the newer "atypical" antipsychotics have mood-stabilizing Other antiepileptic drugs, such as gabapentin (Neurontin), oxcarbazepine (Trileptal), or topiramate (Topamax), are regarded as experimental treatments that sometimes have value for symptoms If you've received a bipolar disorder diagnosis or were just prescribed a new medication, you may wonder what mood stabilizers are and if they have any side effects. (Topamax) lamotrigine The data from open label studies suggest the usefulness of add-on therapy with topiramate in patients with bipolar depression. Studies which have evaluated the role of gabapentin in management of mania have yielded negative results. Learn about medications for bipolar disorder treatment, including lamotrigine, gabapentin, topiramate, and calcium channel blockers. Understand their efficacy, side effects, and benefits for patients. Other medications, like topiramate (Topamax) or gabapentin (Neurontin), may be prescribed in some cases when other treatments haven’t worked. Other anticonvulsants are less well-established for treating mood symptoms in bipolar disorder, and some -- such as Lyrica, Neurontin, or Topamax -- are also used "off label" for other types The subtypes of bipolar disorder include bipolar I and bipolar II. Patients with bipolar I disorder experience manic episodes and nearly always experience hypomanic and major depressive episodes. Bipolar II disorder is marked by at least one hypomanic episode, at least one major depressive episode, and the absence of manic episodes. This post provides only general information about medications used for the treatment of bipolar disorder. It does not cover all possible uses, actions, precautions, side effects, or interactions of the medicines mentioned. Objectives: Topiramate, a structurally novel anticonvulsant, is being evaluated for other neurological conditions such as migraine, neuropathic pain, and essential tremor, and also for psychiatric conditions such as bipolar disorder, bulimia, post-traumatic stress disorder, and schizoaffective disorder, in addition to obesity. In this article, I identify clinical factors associated with complex combination pharmacotherapy for patients with bipolar disorder; describe approaches to ensuring that each component of a treatment regimen has a defined role; discuss the elimination of unnecessary, ineffective, or redundant drugs in a regimen; and address complementary, safe,
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