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Gabapentin isn’t usually used to treat anxiety alone. More often, it’s given to ease anxiety symptoms for someone who also has depression or bipolar disorder. (Anxiety is commonly In one study, women with anxiety, who were previously treated for breast cancer, were given gabapentin 300 mg or 900 mg daily. Compared to placebo (a pill with no medication in it), both doses of gabapentin improved anxiety symptoms after 4 and 8 weeks. Gabapentin may take longer to produce noticeable effects, and its benefits for anxiety may emerge more gradually as the dose is titrated. Both medications share similarities in that they help modulate excitatory neurotransmitters, leading to a calming effect that can alleviate anxiety symptoms. Preclinical data suggest the potential anxiolytic effect of gabapentin ().Recently, Beauclair et al. reported reduction in anxiety symptoms and syndromes in 18 patients with primary psychotic disorders and in one patient with generalized anxiety disorder treated adjunctively with gabapentin, 200–1800 mg/day. But wait, there’s more! Depression and suicidal thoughts can also make an unwelcome appearance. It’s as if gabapentin decided to invite the gloomiest rain cloud to your mental picnic. These feelings can range from a persistent low mood to more severe depressive symptoms. In some cases, patients may experience thoughts of self-harm or suicide. Although evidence is limited, some studies show gabapentin can help with anxiety symptoms. One 2020 review suggests gabapentin may help with different types of situational anxiety, including Objective: Gabapentin is widely prescribed off label in medical practice, including psychiatry. The U.S. Food and Drug Administration (FDA) warned of risks associated with gabapentin combined with central nervous system depressant (CNS-D) drugs, which are commonly prescribed in psychiatric treatment. This study examined off-label outpatient gabapentin use for psychiatric indications and 1. Gabapentin may be effective for treating depression and anxiety, among other things. Although gabapentin was traditionally used to treat seizures, it is now sometimes used as a mood stabilizer for depression and bipolar disorder because it calms neurons in the brain, and it may be effective for anxiety too. Neurontin - also known as Gabapentin - is a drug that is sometimes prescribed to those who experience anxiety especially in situations where the anxiety is co-occurring with bipolar disorder. Previously presumed to have a low abuse and misuse potential, gabapentin has been commonly prescribed for the treatment of anxiety disorders. 10,11 While pregabalin has shown efficacy for generalized anxiety disorder (GAD) in two RCTs, 12,13 the authors could find no such RCTs done for gabapentin. 9 One randomized, double-blind, placebo-controll "I am someone who has a whole laundry list of problems (bipolar II with psychotic features, depression, generalized anxiety, ADHD, panic disorder, and dpdr) so that means I have to take a ton of medication and have been in therapy since I was 13. I just started gabapentin at 300 mg 3x a day and my anxiety is almost nonexistent. While studies don’t typically show effectiveness for improving symptoms of depression, there is evidence that gabapentin may have some benefit for anxiety disorders. A rat study found that gabapentin produced behavioral changes suggestive of anxiolysis, or feelings of calmness. 2002: In one study analyzing the efficacy of Gabapentin as an adjunct treatment for bipolar disorder, it was discovered that improvements were most notable on anxiety-somatization measures of the Hamilton Rating Scale for Depression (HAM-D). Results of the study suggest that those with bipolar disorder who attained the most benefit from Gabapentin can have significant effects on mood, including the potential to cause abnormal changes such as depression, anxiety, and suicidal thoughts. While it is primarily prescribed for conditions like epilepsy and neuropathic pain, its impact on mood should not be underestimated, especially in individuals with preexisting mood disorders. Her anxiety decreased to 0/10 within 48 hours of increasing gabapentin, and she remained in remission on gabapentin monotherapy for the next 70 days despite ongoing psychosocial stressors. At the end of this period, she started to develop some depressive symptoms (Patient Health Questionnaire 9 score of 17), though her anxiety remained mild.
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