neurontin for cough is gabapentin used for epilepsy

In The Lancet, Nicole Ryan and colleagues 1 report on a placebo-controlled, double-blind trial of the effects of gabapentin—a drug used for epilepsy and neuropathic pain—on quality of life, cough frequency, and cough severity in people with chronic cough. This randomised, double-blind, placebo-controlled trial was undertaken at an outpatient clinic in Australia. Adults with refractory chronic cough (>8 weeks' duration) without active respiratory disease or infection were randomly assigned to receive gabapentin (maximum tolerable daily dose of 1800 mg) or matching placebo for 10 weeks. Amitryptiline and gabapentin for example have been shown to have some effect in reducing idiopathic cough [33,52]. The use of gabapentin in chronic cough is reviewed in this series [53]. The mechanisms of action of amitriptyline and gabapentin as treatment for neuropathic pain are likely related to their central anti-nociceptive actions. Gabapentin results in a reduction in cough frequency and cough severity. It improves cough related quality of life. The effect is greatest in patients with features of central reflex sensitisation such as laryngeal paraesthesia, hypertussia and allotussia. Gabapentin, a neurotransmitter modulator, is thought to treat refractory cough associated with interstitial lung disease by improving cough hypersensitivity. This is a single-center, prospective, randomized, double-blind, placebo-controlled trial. Demographic and clinical data, including self-reported cough severity before and after GBP, prior evaluation and treatment for cough, and dosage of GBP were extracted. Results: 18 patients (mean age 60.3 yrs; 22% male; 89% Caucasian) were identified who were prescribed gabapentin for chronic cough. At baseline, all patients reported daily cough. Chronic cough is a neuropathic condition that could be secondary to sensory nerve damage caused by inflammatory, infective and allergic factors. Recent success in the treatment of chronic cough with agents used for treating neuropathic pain such as gabapentin and amitryptiline would also support this concept. Known side effects were explained to patients who had a diagnosis of severely symptomatic idiopathic chronic cough and patients willing to accept the risks participated. 5 Gabapentin was given to 6 patients with idiopathic intractable chronic cough beginning at 100 mg twice per day and titrated until either improvement was manifest or a 1600-mg daily dose was reached. In my experience, effective treatment (cure) of neurogenic cough requires use of medicines that stabilize nerve function, namely, amitriptyline (Elavil) and gabapentin (Neurontin). Chronic (> 4 weeks) cough is one of the most common reasons that people seek attention; however, it is one of the most commonly misdiagnosed and mismanaged medical Gabapentin is effective in the treatment of chronic refractory cough in both subjective and objective evaluations, and its safety is better than other neuromodulators. Keywords: Chronic refractory cough, Gabapentin, Meta-analysis, Efficacy, Safety. 1. Introduction Gabapentin resulted in a significant improvement in cough-specific quality of life, cough severity, and cough frequency and was well tolerated; therefore, it could be considered a viable alternative to current chronic cough treatment, especially for refractory chronic cough. The results of prospective case-series showed that the rate of overall improvement of cough and sensory neuropathy with gabapentin was 68%. Gabapentin treatment of patients with chronic cough showed superior efficacy and a good safety record compared with placebo or standard medications. Additional randomized and controlled trials are needed. And note as well that gabapentin / pregabalin will not work well during upper respiratory infections. We say “viral infection makes the monster thrash around about 3 weeks, before the cough settles back to baseline.” During the 3 weeks, if necessary, we occasionally use tramadol or a similar medication to suppress the cough. Similarities between central reflex sensitisation in refractory chronic cough and neuropathic pain suggest that neuromodulators such as gabapentin might be effective for refractory chronic cough. We established the efficacy of gabapentin in patients with refractory chronic cough. The results of prospective case-series showed that the rate of overall improvement of cough and sensory neuropathy with gabapentin was 68%. Gabapentin treatment of patients with chronic cough showed superior efficacy and a good safety record compared with placebo or standard medications. Additional randomized and controlled trials are needed. Introduction Gabapentin, a neurotransmitter modulator, is thought to treat refractory cough associated with interstitial lung disease by improving cough hypersensitivity. Methods/design This is a single-center, prospective, randomized, double-blind, placebo-controlled trial. The trial will investigate the effect of a 10-week course of oral gabapentin 900 mg/day on refractory cough associated Compared to placebo, patients in the gabapentin arm reported significantly greater improvements in cough-specific quality of life (clinically significant difference measured with Leicester Cough Questionnaire [LCQ]), cough severity (measured with visual analog scale [VAS]), cough frequency (measured with Leicester Cough Monitor [LCM] using Gabapentin results in a reduction in cough frequency and cough severity. It improves cough related quality of life. The effect is greatest in patients with features of central reflex sensitisation such as laryngeal paraesthesia, hypertussia and allotussia. If chronic cough persists even after treatment of the underlying disease, or if the chronic cough is not attributable to any cause, then a symptomatic approach with neuromodulators may be considered, with gabapentin as the first choice, and opioids or macrolides as alternatives. Behavioral cough suppression therapy is a good option for patients with unexplained chronic cough and is recommended by current guidelines. 16 It is hypothesized that behavioral therapy, given by a speech-language pathologist, effectively reduces cough sensitivity, improves voluntary control over cough, and reduces laryngeal muscle tension

neurontin for cough is gabapentin used for epilepsy
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