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Gabapentin is commonly used off-label in the treatment of psychiatric disorders with success, failure, and controversy. A systematic review of the literature was performed to elucidate the evidence for clinical benefit of gabapentin in psychiatric disorders. The next step was to read all of this article’s references. 2-6 Surprisingly, all 5 references focused on the relationship of gabapentin with the use of opioids or in the treatment of pain, with no mention of the common off-label use of gabapentin in various psychiatric disorders such as anxiety and insomnia. Hence, I embarked on a literature These marketing tactics came at a settlement price of US $430 million in criminal and civil liability charges in 2004, 40,43 but led to a tremendous growth in gabapentin prescriptions for off-label use from the early 1990s to early 2000s, 40 a trend that has now shaped modern practice. 44 After the settlement, use of gabapentin for off-label High concomitant use of CNS-D drugs and off-label gabapentin for psychiatric diagnoses underlines the need for improved communication about safety. In this nationally representative sample, <1% of outpatient gabapentin use was for approved indications. The rise in gabapentin prescribing is multifactorial but thought to be due in part to efforts by the pharmaceutical industry to promote the use of the medication for off-label uses. (In 2004, the manufacturer of Neurontin, Pfizer, pleaded guilty to multiple counts of illegally promoting the off-label use of gabapentin, resulting in nearly $430 Gabapentin may be helpful in treating alcohol use disorder and withdrawal. Between 2004 and 2010, The Veterans Affairs Department conducted a double-blind, placebo-controlled, randomized dose gabapentin combined with central nervous system de-pressant (CNS-D) drugs, which are commonly prescribed in psychiatric treatment. This study examined off-label outpatient gabapentin use for psychiatric indications and concomitant CNS-D medication use. Methods: National Ambulatory Care Medical Survey data Gabapentin is an anticonvulsant approved by the FDA for use as an add-on agent in patients with partial seizures resistant to conventional therapies. 4 It is an attractive agent due to flexibility in changing doses, a high therapeutic index, and lack of need to monitor serum levels. 5 As such, gabapentin has been the focus of much attention in More clinical trials with larger patient populations are needed to support gabapentin’s off-label use in psychiatric disorders and substance use disorders. It is worth noting that numerous clinical studies that are discussed in this review are open-label trials, which are inherently less rigorously analyzed. Systematic reviews of gabapentin treatment in psychiatric and/or substance use disorders showed inconclusive evidence for efficacy in BD, but possible efficacy for some anxiety disorders [9, 10 Gabapentin isn’t the main treatment option for anxiety, but it can be an effective alternative when other medications haven’t worked. Doctors may prescribe gabapentin to treat various health Objective: This article reviews evidence-based psychiatric uses of gabapentin, along with associated risks. Method of Research: An extensive literature review was conducted, primarily of articles searchable in PubMed, relating to psychiatric uses, safety, and adverse effects of gabapentin. Explore gabapentin's role in mental health treatment, including its uses, benefits, and potential risks. Learn about dosage, effectiveness, and side effects. This study examined off-label use of gabapentin for psychiatric indications and its concomitant use with CNS-D prescription drugs in a nationally representative sample of ambulatory care office visits. Less than 1% of outpatient gabapentin use was for FDA-approved indications. While gabapentin is frequently used in practice for a wide array of psychiatric diagnoses, its use is evidence-based for only a few indications. Multiple RCTs have shown gabapentin to be ineffective for bipolar disorder. There is insufficient evidence to recommend the use of gabapentin for MDD, GAD, PTSD, or OCD. Gabapentin gained a large market share of AED use in the late 1990s in spite of a lack of randomized clinical trial (RCT) evidence and no labeled indication from the U.S. Food and Drug Administration for its use in psychiatric illness. Objective: Gabapentin is commonly used off-label in the treatment of psychiatric disorders with success, failure, and controversy. A systematic review of the literature was performed to elucidate the evidence for clinical benefit of gabapentin in psychiatric disorders. Objective: Gabapentin (GBP) is an anticonvulsant medication that is also used to treat restless legs syndrome (RLS) and posttherapeutic neuralgia. GBP is commonly prescribed off-label for psychiatric disorders despite the lack of strong evidence. G abapentin was originally approved by the US Food and Drug Administration (FDA) for the treatment of partial seizures in 1993, 1,2 with subsequent approval for postherpetic neuralgia in 2002. 3–5 Within a decade of initial FDA approval, gabapentin’s second most common use became off-label prescription for psychiatric disorders. 6 There are several drugs that may be prescribed for anxiety that were not developed originally for anxiety treatment. One such drug is Neurontin. Neurontin - also known as Gabapentin - is a drug that is sometimes prescribed to those who experience anxiety especially in situations where the anxiety is co-occurring with bipolar disorder.
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