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Gabapentin is an approved treatment as an adjunctive therapy in the management of epilepsy. However, it is most commonly prescribed off-label for other conditions, including anxiety , alcohol use disorder , and chronic pain. Neurontin is also referred to by its drug name, Gabapentin. Neurontin is an anticonvulsant, or drug that controls seizures. In cases of depression, Neurontin works as a mood stabilizer. How do I take it? Prescribing information states that Neurontin should be taken three times a day. Neurontin comes in tablet, capsule, and liquid solution forms. Currently, the most useful mood stabilizer combinations are the mixtures of anticonvulsants and lithium, particularly valproate plus lithium. Carbamazepine, lamotrigine, and gabapentin have also been added to lithium with apparent safety. If used as a mood stabilizer or anti-depressant, the dose is usually between 900 and 2,000 mg a day. But, it may also be increased for better results. American Psychological Association: Gabapentin has been “largely discredited as a mood stabilizer for bipolar disorder.” Depression and Bipolar Support Alliance: Gabapentin “was used frequently for treatment of bipolar disorder, but controlled studies found it was no more effective than a placebo.” Gabapentin (Neurontin) is FDA approved to treat seizure disorder and nerve pain from shingles. But it’s also used off-label to treat many other conditions, including anxiety, nerve pain from diabetes, and hot flashes. Gabapentin may be effective for anxiety, but it’s usually not a first-choice medication for this use. Adjunctive therapy of gabapentin to stable doses of mood stabilizers or atypical antipsychotics, initiated at 300 mg at bedtime and increased by 300 mg every four nights until symptom relief or adverse effects were noted. Final GBP dose was clinically determined. Maximum dose 3600 mg per day in divided doses (range 600 mg to 3300 mg). Although gabapentin was traditionally used to treat seizures, it is now sometimes used as a mood stabilizer for depression and bipolar disorder because it calms neurons in the brain, and it may be effective for anxiety too. The gabapentinoids, gabapentin, and pregabalin, target the α2δ subunits of voltage-gated calcium channels. Initially licensed for pain and seizures, they have become widely prescribed drugs. For 1 year, 13 patients received adjunctive gabapentin with standard mood stabilizers and 12 patients received adjunctive placebo. On the basis of the CGI-BP, gabapentin-treated patients showed significant improvement from baseline to month 12. According to Psycom, gabapentin for depression may follow a different dosage pattern. Dosage of between 900 and 2,000 mg a day works as a mood stabilizer or antidepressant. Some people experience improvement within a week after treatment initiation, others need more time to feel significant symptom relief. Gabapentin is currently being studied as a treatment for bipolar disorder, and there have been favorable reports regarding its potential as a mood stabilizer (82, 83). The advantages of gabapentin include the lack of interactions with other drugs in the cytochrome P450 system and the lack of protein binding ( 84 ). Evidence supports gabapentin as a treatment for alcohol withdrawal and alcohol use disorder. There is sufficient evidence to consider gabapentin as a third-line treatment for social anxiety disorder and severe panic disorder. Mood Stabilizing Medications. Lithium (Eskalith or Lithobid) Valproate/Valproic Acid/Divalproex Sodium (Depakote or Depakene) Carbamazepine (Equetro or Tegretol) Lamotrigine (Lamictal) Oxcarbazepine (Trileptal) Gabapentin (Fanatrex, Gabarone, Horizant, or Neurontin) Topiramate (Topamax or Topiragen) Oxcarbazepine (Trileptal) Side Effects of My psychiatrist recently put me on Gabapentin for as a mood stabilizer/ to address anxiety and depression ( we're exploring a possible Bipolar II diagnosis as well). I'm not taking any other meds and have had negative reactions to several SSRIs. What have people's experiences been with taking Gabapentin on it's own as a mood stabilizer? For 1 year, 13 patients received adjunctive gabapentin with standard mood stabilizers and 12 patients received adjunctive placebo. On the basis of the CGI-BP, gabapentin-treated patients showed significant improvement from baseline to month 12. Mood Stabilizing Medications. Lithium (Eskalith or Lithobid) Valproate/Valproic Acid/Divalproex Sodium (Depakote or Depakene) Carbamazepine (Equetro or Tegretol) Lamotrigine (Lamictal) Oxcarbazepine (Trileptal) Gabapentin (Fanatrex, Gabarone, Horizant, or Neurontin) Topiramate (Topamax or Topiragen) Oxcarbazepine (Trileptal) Side Effects of medications, mood stabilizer use and dosage, evidence regarding poor response to standard mood stabilizers be-fore gabapentin use, evidence regarding whether during gabapentin treatment mania or hypomania occurred, ad-verse events, maximum and maintenance gabapentin dose and duration of treatment, indications for treatment Mood stabilizers may help with depressive symptoms in people with bipolar disorder. Each medication may have different side effects. What are mood stabilizers? There is more than one class of Some research suggests that gabapentin might have mood-stabilizing properties, potentially helping with conditions like bipolar disorder. It’s like the medication is acting as an emotional shock absorber, smoothing out the highs and lows.
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