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A total of 27 high-quality studies were described. The prevalence of gabapentinoid use during pregnancy remained very low, at less than 1%. Five studies reported significant findings with increased risks of overall congenital anomalies, specific anomalies (nervous system, eyes, oro-facial clefs, urinary and genital system), miscarriage, stillbirth and specific neurodevelopmental outcomes after Gabapentin is not generally recommended in pregnancy as there is not enough information about its safety for your baby. It should only be taken if the benefits outweigh the risks. If you take gabapentin for epilepsy, you may need to change to a different medicine. Gabapentin (Neurontin) is an antiepileptic drug that may cause birth defects and harm the fetus. Learn about the risks, benefits, and alternatives of using gabapentin during pregnancy and breastfeeding. Does taking gabapentin increase the chance of birth defects? Every pregnancy starts out with a 3-5% chance of having a birth defect. This is called the background risk. Small, controlled studies on gabapentin have not suggested an increased chance of birth defects. Selected References: Blotiere PO, et al. 2020. Risk of early neurodevelopmental outcomes associated with prenatal exposure to the antiepileptic drugs most commonly used during pregnancy: a French nationwide population-based cohort study. BMJ Open 10(6). Brannon GE, Rolland PD. Anorgasmia in a patient with bipolar disorder type 1 treated with gabapentin. J Clin Psychopharmacol. 2000;20(3):379 Gabapentin is a γ-aminobutyric acid analog formally indicated for the treatment of epilepsy and neuropathic pain that is gaining increased popularity. Gabapentin has been historically considered a safe medication, including during pregnancy and lactation, with low reported concerns for misuse and us There was an increased risk of preterm birth among women exposed to gabapentin either late (RR=1.28 [CI 1.08-1.52], p < 0.01) or both early and late in pregnancy (RR=1.22 [1.09-1.36], p < 0.001). Due to mixed findings on its safety during pregnancy, gabapentin shouldn’t be taken during pregnancy without first discussing it with your doctor. Gabapentin (Neurontin) is an anti-seizure medication that’s also used for certain types of neuropathic pain. We examined the risk of major congenital malformations and cardiac defects associated with gabapentin exposure during the first trimester (T1), and the risk of preeclampsia (PE), preterm birth (PTB), small for gestational age (SGA), and neonatal intensive care unit admission (NICUa) associated with gabapentin exposure early, late, or both early It is not known if gabapentin can make it harder to get pregnant. Sexual dysfunction (including loss of desire to have sex and loss of ability to have an orgasm) has been reported among women who take gabapentin. More research is required to define the pregnancy safety profile of gabapentin. Pregnant women and women of childbearing potential should be made aware of the lack of data for most pregnancy outcomes. Gabapentin should only be used during pregnancy where benefits of treatment are considered to outweigh any potential risks. While the available information does not strongly suggest that it causes problems for the baby, further research is required to prove that gabapentin is safe. As a precaution, gabapentin is only prescribed in pregnancy when the benefits (most commonly of controlling seizures in women with epilepsy) outweigh the possible risks. The last decade has seen a significant increase in gabapentin prescriptions among pregnant people, particularly for off-label use, despite limited evidence of its safety during pregnancy. 6-8 Despite the lack of reports on the teratogenicity of gabapentin, it has been associated with the potential risk of congenital malformations, including While the available information does not strongly suggest that it causes problems for the baby, further research is required to prove that gabapentin is safe. As a precaution, gabapentin is only prescribed in pregnancy when the benefits (most commonly of controlling seizures in women with epilepsy) outweigh the possible risks. While gabapentin (Neurontin) is now used in a wide variety of clinical settings — for epilepsy, pain management, restless leg syndrome, anxiety, and sleep disturbance – there is relatively little information regarding its reproductive safety. Pregnancy-related problems, such as preterm delivery (birth before week 37) or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth) have been reported in some studies looking at the use of gabapentin during pregnancy. To provide evidence on the safety of gabapentin use in pregnancy, we conducted a large. cohort study of pregnant women within the US Medicaid Analytic eXtract (MAX) [12] and. Because of the increasing use of gabapentin in many settings of care and the limited information on its safety in pregnancy, there is a critical need for evidence to help pregnant women or women of childbearing age and their healthcare providers to balance the risks and benefits of gabapentin treatment with regard to pregnancy-related outcomes. To provide evidence on the safety of gabapentin use in pregnancy, we conducted a large cohort study of pregnant women within the US Medicaid Analytic eXtract (MAX) and assessed a range of neonatal and maternal outcomes. Considering the increasing number of pregnant women who may be taking gabapentin for other conditions during pregnancy, such as restless legs syndrome, 7 and paucity of information regarding the safety of this medication in pregnancy, more information regarding fetal safety is required.
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