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The common side effects of Pregabalin include dry mouth, blurred vision, headache, weight gain, indigestion, and constipation. At the same time, the common side effects of Gabapentin include – shaking, diarrhea, dizziness, drowsiness, and weakness. A. Weight gain is among the most common side effects of pregabalin, reported by up to 14 percent of patients taking it (Federal Practitioner, May 2021). Sadly, we could not find studies demonstrating that reducing the dose results in weight loss. Lyrica and its popular predecessor Gabapentin (Neurontin) have both been shown to cause significant weight gain. In a 2008 study, patients taking Lyrica for epilepsy, gained approximately 4 kg (8 lb) in a 3 to 6-month period. Lyrica is more likely than gabapentin to cause side effects such as dry mouth, constipation, swelling (edema), breast enlargement, or weight gain; Gabapentin is more likely than Lyrica to cause side effects such as difficulty speaking, fever, an increased risk of viral infections, unusual eye movements, or jerky movements Why? Both have numerous side effects and are potentially dangerous. There are many side effects that are considered “normal” for Lyrica and Neurontin. The following outlines some of the “common” side effects of Lyrica and Neurontin: Experiencing Weight Gain-some gain as much as 40 pounds the first year; Blurred Vision; Body Tremors Is Weight Gain Common With Gabapentin? Weight gain is not considered a common side effect of gabapentin. In clinical trials, only about 2% of people reported weight gain with its use. In people who do gain weight while on gabapentin, a research study showed a weight gain of about 5.5 pounds after 1.5 months of use. Weight gain; Enlarged breasts Gabapentin is more likely to cause different side effects from pregabalin, including: Whether your doctor prescribes gabapentin or pregabalin will depend on The report further stated that pregabalin, analogous to gabapentin, can cause weight gain and peripheral edema in elderly persons. However, a study by Ghai et al. (2011) involving 90 women with abdominal hysterectomy pain reported that pregabalin is associated with fewer dose-related adverse reactions than gabapentin. Researchers speculate that Another troubling side effect is weight gain (11 percent). The most frequently reported side effect is headache for gabapentin (27 percent). Nausea (21 percent) is another frequent side effect. Gabapentin appears more helpful for treating fibromyalgia, but the side effects of the two drugs may be your deciding factor. Lyrica (pregabalin) and weight gain. Weight gain is one of the possible side effects of taking pregabalin (Lyrica) as prescribed. However, the majority of patients prescribed Lyrica won’t gain weight or will gain only a small amount. The reported incidence of weight gain from Lyrica ranges from 2% to 14.8% of patients. DailyMed. Label: pregabalin capsule.. DailyMed. Label: gabapentin capsule.. Baldwin DS, den Boer JA, Lyndon G, Emir B, Schweizer E, Haswell H. Efficacy and safety of pregabalin in generalised anxiety disorder: a critical review of the literature. Yes, pregabalin can cause weight gain, with about 9% of patients experiencing an increase of 7% or more of their initial body weight. Pregabalin weight gain is usually moderate, with an average gain of around 1.6 kg (3.5 lbs) in clinical trials. In people with postherpetic neuralgia, 2% of patients taking gabapentin experienced weight gain. No weight gain was found among people taking the placebo. The cause of weight gain with gabapentin is likely due to increased appetite. You may be hungry more often. In some cases, weight gain may be due to fluid retention, another side effect of Pregabalin is rapidly and completely absorbed as compared to gabapentin. Peak plasma concentrations are seen within an hour as compared to 3 hours with gabapentin. 12 Oral bioavailability for pregabalin is more than 90% as compared to 30–60% for gabapentin. These differences can be explained by the mechanism of absorption. See what Lyrica users say about weight gain. Out of 925 reviews, 152 (16.4%) mention weight gain. Some people have a better time on Lyrica, some on Gabapentin. I Weight gain is likely: Both gabapentin and pregabalin are associated with a variable amount of weight gain (due to increased appetite and/or oedema), which is dose dependent and typically occurs between 2 – 12 months after initiation. 1 Most patients taking pregabalin maintain their weight within ± 7% of their baseline weight, but up to 16% A review of research examining antipsychotic medicine explains why: Most of those drugs cause weight gain. Over the course of treatment, around 7 in 10 patients will gain weight — rapidly in the initial period after starting these meds, but it continues over the long term. The risk appears to be highest with: Olanzapine (Zyprexa) Clozapine One side effect that’s more common with pregabalin is weight gain. This side effect doesn’t appear to be linked to fluid buildup, but it’s something to pay attention to if you’re starting pregabalin. Yes, weight gain is one of the most common side effects with Lyrica (generic name: pregabalin) in both adults and children. In studies that were 14 weeks long in adults, 9% of Lyrica-treated patients and 2% of placebo (inactive treatment) patients gained 7% or more over their weight at the beginning of the study. Pregabalin is more likely to cause weight gain, with a reported incidence between 2 and 14%. 8 Weight gain may be associated with dose and duration; 1 study demonstrated an average weight gain of about 11 lb after 2 years of pregabalin treatment. 8 The medical literature lacks information regarding weight gain associated with combination
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