Is gabapentin dangerous in pregnancy? Because the risks of taking gabapentin while pregnant in humans are not fully understood, use of gabapentin during pregnancy is determined on a case-by-case basis to determine if the benefits outweigh the risks. Gabapentin is a pregnancy category C, which means risk cannot be ruled out. We sought to evaluate the association between gabapentin exposure during pregnancy and risk of adverse neonatal and maternal outcomes. Methods and findings: Using the United States Medicaid Every pregnancy starts out with a 3-5% chance of having a birth defect. This is called the background risk. Small, controlled studies on gabapentin have not suggested an increased chance of birth defects. There is also no known pattern of birth defects associated with the use of gabapentin in pregnancy. More research is required to define the pregnancy safety profile of gabapentin. Pregnant women and women of childbearing potential should be made aware of the lack of data for most pregnancy outcomes. Gabapentin should only be used during pregnancy where benefits of treatment are considered to outweigh any potential risks. To provide information regarding the effects of in utero exposure to this drug, pregnant patients should be encouraged to enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry. This can be done by calling the toll-free number 1-888-233-2334 and must be done by patients themselves. As a precaution, gabapentin is only prescribed in pregnancy when the benefits (most commonly of controlling seizures in women with epilepsy) outweigh the possible risks. Women taking gabapentin while trying to conceive and during pregnancy should therefore be prescribed a high dose folic acid supplement (5mg/day). The researchers reported 2 major malformations in infants exposed to gabapentin in the first trimester of pregnancy. 3 In another group of 7 women with hyperemesis gravidarum, 2 congenital defects were reported. 4 A cohort study in Denmark reported on 59 fetuses exposed to gabapentin during pregnancy, and documented 1 major malformation and 6 treating your condition and the risks of untreated illness during pregnancy. I take gabapentin. Can it make it harder for me to get pregnant? It is not known if gabapentin can make it harder to get pregnant. Sexual dysfunction (including loss of desire to have sex and loss of ability to have an orgasm) has been reported among women who take Taken together, the current literature suggests that gabapentin use should be considered with caution during pregnancy and during the post-partum period. Well-controlled, prospective research studies are needed to determine the extent of the risks and benefits of prescribed and nonprescribed gabapentin exposure to pregnant people and their The last decade has seen a significant increase in gabapentin prescriptions among pregnant people, particularly for off-label use, despite limited evidence of its safety during pregnancy. 6-8 Despite the lack of reports on the teratogenicity of gabapentin, it has been associated with the potential risk of congenital malformations, including As a precaution, gabapentin is only prescribed in pregnancy when the benefits (most commonly of controlling seizures in women with epilepsy) outweigh the possible risks. Women taking gabapentin while trying to conceive and during pregnancy should therefore be prescribed a high dose folic acid supplement (5mg/day). Every pregnancy starts out with a 3-5% chance of having a birth defect. This is called the background risk. Small, controlled studies on gabapentin have not suggested an increased chance of birth defects. There is also no known pattern of birth defects associated with the use of gabapentin in pregnancy. Additionally, gabapentin can cause multiorgan hypersensitivity or DRESS syndrome, a serious condition that requires immediate medical attention if symptoms such as rash, fever, swollen lymph nodes, or liver problems occur.Consulting with a healthcare professional and being aware of the potential risks and benefits of gabapentin are important Because of the increasing use of gabapentin in many settings of care and the limited information on its safety in pregnancy, there is a critical need for evidence to help pregnant women or women of childbearing age and their healthcare providers to balance the risks and benefits of gabapentin treatment with regard to pregnancy-related outcomes. Abstract Background. Despite the widespread use, only sparse information is available on the safety of gabapentin during pregnancy. We sought to evaluate the association between gabapentin exposure during pregnancy and risk of adverse neonatal and maternal outcomes. While gabapentin may be an effective treatment for certain conditions, including epilepsy and nerve pain, it is important to consider alternative treatments if you are pregnant or planning to become pregnant. The risks associated with taking gabapentin during pregnancy are still being studied, and it is not yet known how it may affect the We examined the risk of major congenital malformations and cardiac defects associated with gabapentin exposure during the first trimester (T1), and the risk of preeclampsia (PE), preterm birth (PTB), small for gestational age (SGA), and neonatal intensive care unit admission (NICUa) associated with gabapentin exposure early, late, or both early Gabapentin and pregnancy. Gabapentin is not generally recommended in pregnancy as there is not enough information about whether it's safe for your baby. However, from the small amount of information that is available, there's no clear evidence that it's harmful. It should only be taken if the benefits of the medicine outweigh the risks. Gabapentin/early and late in pregnancy (at least one dispensing in the first 140 days and at least one in the 141 and 245 days of pregnancy)1275 pregnancies (0.07%) [35] Richards et al., 2018: Gabapentin/during pregnancy: 2009: 0.27 women per 1000 births 2014: 0.97 women per 1000 births [31] Shouman et al., 2022: Gabapentin/during pregnancy
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