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Gabapentin presents a promising option for managing hot flashes, particularly for those who haven’t found relief through other treatments. By understanding its benefits, potential side effects, and proper administration, you can make informed decisions about its use. This antiseizure medicine helps ease hot flashes. Side effects can include being drowsy, dizzy or tired and swelling in the arms and legs, called edema. Pregabalin (Lyrica). This is another anti-seizure medicine that can help ease hot flashes. Side effects can include being drowsy and dizzy, having trouble focusing, and gaining weight. Gabapentin has an average rating of 8.7 out of 10 from a total of 111 reviews for the off-label treatment of Hot Flashes. 87% of reviewers reported a positive experience, while 8% reported a negative experience. Fortunately, a new treatment option may be able to treat hot flashes without the risk. Gabapentin, an anticonvulsant, may be effective for the treatment of hot flashes. Often sold as Neurontin, gabapentin is approved by the Food and Drug Administration (FDA) for the treatment of epilepsy. Gabapentin is an antiseizure medication that some people use for hot flashes. While the FDA has not approved this medication for hot flashes, it is an effective option for some individuals. Gabapentin can be considered effective in the treatment of hot flashes and should be considered a reasonable alternative when estrogen therapy is not desired. Hot flashes occur frequently in menopausal women and in women with breast cancer, diminishing their quality of life. Gabapentin Helps Hot Flashes. In BREEZE 3, 600 postmenopausal women (mean age, 54.0 years; mean time since last menstrual period, 114 months; mean body mass index, 29.4 kg/m²) were randomized to earched the PubMed, MEDLINE, EMBASE, and CENTRAL databases for English-language articles published until June, 2018. The following search terms were used: “menopause,” “hot flushes,” “vasomotor symptoms,” “gabapentin,” and “non-hormonal therapy.” Primary outcomes were frequency, duration, and composite score of hot flushes. Secondary outcomes were adverse effects and Gabapentin is a GABA analogue used in the treatment of epilepsy, neurogenic pain, restless-leg syndrome, essential tremor, bipolar disorder, and migraine prophylaxis; it was first reported for its effects on hot flashes in five women and one man. 19 A randomised double-blind, placebo-controlled trial has shown that gabapentin is effective in Gabapentin 300 mg/day could be useful to relieve hot flashes in women for whom hormone therapy is not suitable or when hot flashes do not respond to other therapies. Further researches are needed to determine the efficacy of gabapentin use for longer periods or at higher doses. After one week, used for baseline documentation of hot flash frequency and severity, patients received one of four oral treatment regimens: 300mg gabapentin daily for 28 days, versus 300 mg gabapentin daily for 7 days and then twice daily for 21 days, versus 300mg gabapentin daily for 7 days then twice daily for 7 days and then thrice daily for "For those that have breast cancer — or have had a heart attack, or a stroke or a blood clot — and are having hot flashes and night sweats and can't use hormone therapy, this is another option that they can consider to treat their quality of life-impacting hot flashes and night sweats," says Dr. Kling. Hormone therapy for menopause There are several good quality clinical trials that address gabapentin for hot flashes and it has even been the subject of a recent meta-analysis. In studies, gabapentin reduced hot flashes from 45%-71% depending on the dose. A 2005 study by Pandya et al. randomized 420 women with breast cancer and experiencing at least 2 hot flashes in 24 hours to one of three groups: gabapentin 300 mg daily, gabapentin 900 mg daily, or placebo 23. After 8 weeks, the 300 mg dose group showed a modest 20% reduction in hot flashes, but the 900 mg dose group showed a reduction of 4. Pandya KJ, Morrow GR, Roscoe JA, et al. Gabapentin for hot flashes in 420 women with breast cancer: a randomised double-blind placebo-controlled trial. Lancet 2005;366:818-24. 5. Guttuso T, Jr., Kurlan R, McDermott MP, Kieburtz K. Gabapentin's effects on hot flashes in postmenopausal women: a randomized controlled trial. Gabapentin at 900 mg/day was an effective treatment of hot flashes in women who entered menopause naturally. Gabapentin at 900 mg/day was associated with a 51% reduction in hot flash scores from baseline to week 4. The average frequency of hot flashes decreased from 8.5 per day at baseline to 4.5 per day with gabapentin by week 4.
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