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The results revealed that the risk of dementia associated with gabapentin or pregabalin exposure was significant in all subgroups except for the strata having depression or head injury. The risk of dementia development was higher in the younger group (age <50 years) than that in the older group. Applying the inclusion and exclusion criteria yielded 201,492 patients for the study: 25,373 in the dementia cohort and 174,930 in the non-dementia cohort. Post 1:1 matching, and after excluding recent gabapentin use (within three months of the index date), the study comprised 22,769 individuals in the dementia cohort and 22,644 in the non-dementia Gabapentin is an effective treatment for chronic neuropathic pain but may cause dizziness, drowsiness, and confusion in some older adults. The goal of this study was to assess the association between gabapentin dosing and adverse outcomes by There has been an ongoing debate on whether gabapentin and memory loss are linked. However, it seems that Gabapentin alone cannot cause memory loss, but when combined with similar drugs like baclofen, it can. One study found that long-term administrations of Gabapentin alone did not cause memory loss or memory impairment. Especially in older adults, gabapentin is prescribed to treat behavioral and psychological symptoms of dementia (BPSD) (Kim et al., 2008). Several studies have reported that gabapentin has a deleterious effect on cognition (Leach et al., 1997; Meador et al., 1999; Shem et al., 2018). How they can affect memory: Patients who take anticholinergics can have complications with their long-term memory, says Merrey. These medications have been associated with an increased risk of dementia, and that heightened risk can persist even after the medication has been discontinued. While studies haven’t definitively confirmed gabapentin causes long-term memory loss or impairment as severe as dementia, patients can experience brain fog and slight confusion. However, it is important to acknowledge the existing evidence that links long-term gabapentin use to cognitive decline including memory. The evidence of gabapentin and dementia is mixed, with two studies looking at hundreds of thousands of people and coming to completely different conclusions. This large, robust study showed a definite link between anticholinergic medications and patients who have dementia, but it didn’t prove that there was a direct cause. Two common classes of drugs have been linked to dementia. Fortunately, there are alternatives to both. If you're worried about developing dementia, you've probably memorized the list of things you should do to minimize your risk—eating a healthy diet, exercising regularly, getting adequate sleep, and keeping your mind and soul engaged. Gabapentin use was significantly associated with decline in cognitive and functional status among older adults with initially normal cognition. Further studies are needed to examine the association. Medications that have been associated with increased risk of dementia include overactive bladder medications, pain medications, heartburn medications, and certain anxiety medications. The risk of dementia with these medications increases when you take higher doses over longer periods of time. The prevalence of gabapentin use increased from 2006 to 2019, both in overall population and within every subgroup (i.e., cognitive status, age group, and sex). About 10–30% of gabapentin users reported to concurrently use gabapentin with opioids. Over one-half of gabapentin users with dementia concurrently used gabapentin with antidepressants. Gabapentin use has been associated with memory loss and cognitive decline. Studies suggest that the risk of dementia may be higher in patients treated with gabapentin. It is important for patients and healthcare providers to be aware of the potential cognitive side effects of gabapentin. Gabapentin is an effective treatment for chronic neuropathic pain but may cause dizziness, drowsiness, and confusion in some older adults. The goal of this study was to assess the association between gabapentin dosing and adverse outcomes by obtaining estimates of the 30-day risk of hospitalization with altered mental status and mortality in older adults (mean age 76 years) in Ontario, Canada Our analysis suggests that in patients with chronic pain, long-term gabapentin use does not markedly alter dementia risk across varying cumulative dosages, regardless of age or gender. These findings may have significant implications for chronic pain management and underscore the potential cognitive safety of prolonged gabapentin administration. Moreover, the stratification analysis revealed that the risk of dementia associated with gabapentin or pregabalin exposure was significant in all age subgroups; however, it was higher in younger patients (age <50) than in the older patients (hazard ratio, 3.16; 95% CI, 2.23-4.47). Gabapentin has been increasingly prescribed to older adults for off-label indications, and accumulating evidence suggests potential for gabapentin misuse and related adverse events. However, the relation between gabapentin initiation and longer-term neurocognitive changes is not well understood. Some studies report that gabapentin can cause erectile dysfunction in men. However, older studies also report cases of sexual dysfunction and loss of libido in women. Additionally, the side The multivariate-adjusted hazard ratio of risk of dementia for gabapentin or pregabalin exposure versus the matched non-exposed group was 1.45 (95% confidence interval [CI], 1.36–1.55). The risk of dementia increased with higher cumulative defined daily doses during the follow-up period.
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