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Gabapentin is frequently used in the treatment of anxiety disorders. However, there are no randomized controlled trials on the effectiveness of this medication in generalized anxiety disorder (GAD), and there are only a few case reports. Previously presumed to have a low abuse and misuse potential, gabapentin has been commonly prescribed for the treatment of anxiety disorders. 10,11 While pregabalin has shown efficacy for generalized anxiety disorder (GAD) in two RCTs, 12,13 the authors could find no such RCTs done for gabapentin. 9 One randomized, double-blind, placebo-controll Gabapentin patients reported less anxiety, less sedation, and decreased alcohol craving compared to the lorazepam group. 73 In a small double-blind, randomized study of 26 veterans with alcohol dependence undergoing outpatient alcohol detoxification, Stock et al 74 showed that gabapentin treatment reduced sedation and may decrease alcohol A clear pattern of remission or mild anxiety on total daily doses of gabapentin ≥ 900 mg/day and severe anxiety at doses < 600 mg/day was observed. In the absence of randomized controlled trials, these findings may offer clinically important clues about dosing and effectiveness of gabapentin in GAD. Gabapentin is an anticonvulsive medication that received approval from the US Food and Drug Administration (FDA) in 1993 and has been available in generic form in the USA since 2004. Gabapentin was originally used as a muscle relaxant and an anti-spasmodic. However, it was later discovered that gabapentin has the potential of an anticonvulsive medication and can be used as an adjunct to more Selective serotonin reuptake inhibitors and SNRIs are both first-line treatments for PD, GAD, and SAD and have been shown to be efficacious for the treatment of anxiety disorders (13 – 16). In one study, women with anxiety, who were previously treated for breast cancer, were given gabapentin 300 mg or 900 mg daily. Compared to placebo (a pill with no medication in it), both doses of gabapentin improved anxiety symptoms after 4 and 8 weeks. A very small study also found that gabapentin was helpful for treating social anxiety disorder. The aim of this study was to compare the effect of 3 treatment arms (placebo, gabapentin 300mg daily, gabapentin 900mg daily) on anxiety at 4 weeks and 8 weeks, respectively. Therefore, the primary efficacy variable was defined as the mean anxiety score at 4 weeks and 8 weeks, respectively. Although evidence is limited, some studies show gabapentin can help with anxiety symptoms. One 2020 review suggests gabapentin may help with different types of situational anxiety, Visual inspection of a funnel plot for gabapentin versus placebo in preoperative anxiety suggested possible small study effects, with greater effect size being observed in high-dose gabapentin studies with smaller samples (Supplementary Appendix, Fig. 5.1). Our preliminary observations suggest a role for gabapentin as monotherapy or for adjunctive use in patients with panic disorder or generalized anxiety disorder. The promising preliminary results encourage further clinical exploration and systematic study of gabapentin for the treatment of anxiety disorders. Our analysis of all anxiety-related studies showed statistically significant low to large effect sizes favoring gabapentinoid use, compared to placebo, across the spectrum of anxiety Anxiety reduction: Most studies suggest that Gabapentin is an effective treatment for anxiety. Although it hasn’t been formally approved by the FDA, nearly every study analyzing its anxiolytic effect has found some degree of benefit. [PMC free article] [Google Scholar]; • This study, the Child/Adolescent Anxiety Multimodal Study is the largest evaluation of pharmacotherapy, combined pharmacotherapy and cognitive behavioral therapy in youth. [13]. Strawn JR, Sakolsky DJ, Rynn MA. Psychopharmacologic treatment of children and adolescents with anxiety disorders. Gabapentin is safe for cats and is commonly prescribed by veterinarians to treat pain, anxiety, and feline hyperesthesia syndrome. It has a low risk of side effects when taken at the correct dosage. Mild sedation and lethargy are the most common side effects but these tend to get better with continued dosing. Gabapentin and pregabalin both have RCTs showing efficacy over placebo for social anxiety disorder; however, it should be noted that improvement was associated with higher doses than are often tolerated (e.g., >2,100 mg daily for gabapentin and 600 mg total daily for pregabalin) (113–115).
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