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There are several possible explanations for gabapentin weight gain: Fatigue : The most common side effect, which can lead to less activity and more eating. Increased hunger : The medication can make you feel hungrier than usual, which can make it difficult to avoid gaining weight. Gabapentin is also sometimes used to relieve the pain of diabetic neuropathy (numbness or tingling due to nerve damage in people who have diabetes) The most common adverse reactions associated with the use of this drug were dizziness, somnolence, and peripheral edema. Gabapentin may cause weight gain by increasing your appetite, causing fluid retention, and inhibiting physical activity by causing fatigue. Because gabapentin is an anticonvulsant, it prevents seizures and nerve pain by reducing nerve activity in the central nervous system. Lyrica is more likely than gabapentin to cause side effects such as dry mouth, constipation, swelling (edema), breast enlargement, or weight gain Gabapentin is more likely than Lyrica to cause side effects such as difficulty speaking, fever, an increased risk of viral infections, unusual eye movements, or jerky movements More rarely, gabapentin can cause fluid buildup (edema), weight gain, and vision problems. It can also cause diarrhea. More serious (but rare) side effects include suicidal thoughts or behavior, and mood changes in children. Gabapentin, a medication commonly used to treat neuropathic pain and seizure disorders, has been associated with weight gain in some patients. This article synthesizes findings from multiple studies to provide a clear understanding of the relationship between gabapentin and weight gain. Gabapentin can impair thinking and motor skills and may cause drowsiness. It is advised not to drive or operate heavy machinery until you know how the medication affects you. Use caution when combining gabapentin with other drugs that cause drowsiness. Multiorgan hypersensitivity and DRESS syndrome weight gain; Managing side effects Blumhardt L, Chadwick D (1987) "Gabapentin as an antiepileptic drug in man." J Neurol Neurosurg Psychiatry, 50, p. 682-6. 7 Weight gain was associated with the use of amitriptyline (1.8 kg), mirtazapine (1.5 kg), olanzapine (2.4 kg), quetiapine (1.1 kg), risperidone (0.8 kg), gabapentin (2.2 kg), tolbutamide (2.8 kg), pioglitazone (2.6 kg), glimepiride (2.1 kg), gliclazide (1.8 kg), glyburide (2.6 kg), glipizide (2.2 kg), sitagliptin (0.55 kg), and nateglinide (0.3 kg). Weight gain. Movement problems: coordination problems, being unsteady, tremors, jerky movements. Serious breathing problems can happen if you take gabapentin with Weight gain is not considered a common side effect of gabapentin. In clinical trials, only about 2% of people reported weight gain with its use. In people who do gain weight while on gabapentin, a research study showed a weight gain of about 5.5 pounds after 1.5 months of use. In addition to these FDA-approved uses, doctors sometimes prescribe gabapentin off-label. Off-label use means there is some evidence to show that a drug may be medically appropriate to treat conditions other than those for which it was approved. Gabapentin is sold under the brand name Neurontin and is available as a generic product as well. My Dr. said that Lyrica (pregabalin) causes terrible weight gain, but not Gabapentin. I have read that weight gain on Gabapentin can be dose-related. I’ve noticed that I do get hungry more often, so I log everything I eat to make sure I’m not eating too much. I’m still wearing the same size clothing after 2 years, so the weight gain isn Gabapentin may cause weight gain, but it is an uncommon side effect. Studies have shown that a small number of people taking gabapentin, a drug used to treat epilepsy and postherpetic neuralgia, experienced weight gain. People who do gain weight may gain about 5 pounds after 6 weeks of use. Weight gain from gabapentin unrelated to peripheral edema isn’t very common. To avoid weight gain from gabapentin, make sure you’re taking the dose your prescriber recommends. Taking higher doses of gabapentin increases your risk of weight gain and severe side effects like extreme drowsiness. A review of research examining antipsychotic medicine explains why: Most of those drugs cause weight gain. Over the course of treatment, around 7 in 10 patients will gain weight — rapidly in the initial period after starting these meds, but it continues over the long term. The risk appears to be highest with: Olanzapine (Zyprexa) Clozapine See what Gabapentin users say about weight gain. Out of 2570 reviews, 97 (3.8%) mention weight gain. Read firsthand experiences. Certain medications used to treat seizures, also known as antiepileptic drugs (AEDs) or antiseizure medications (ASMs), may cause weight gain for some people. Weight gain or body fat redistribution are common side effects of many widely used drugs. Weight gain amounts varying between a few kg to an increase of 10% or more of initial body weight have been described. Often accompanying this weight gain are worsened health risks, including an increased incidence of the metabolic syndrome, type 2 diabetes, and other cardiovascular risk factors. With Gabapentin (Neurontin, Gralise, Horizant) is a medicine used to treat partial seizures, nerve pain from shingles and restless leg syndrome. It works on the chemical messengers in your brain and nerves. Gabapentin is from a group of medicines called anticonvulsants.
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