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Drug Interactions: A total of 447 drugs are known to interact with Cyclobenzaprine: 91 major drug interactions (462 brand and generic names) 350 moderate drug interactions (1398 brand and generic names) 6 minor drug interactions (13 brand and generic names) A total of 270 drugs are known to interact with Gabapentin: Compare Flexeril vs Gabapentin head-to-head with other drugs for uses, ratings, cost, side effects and interactions. What are the more common side effects of gabapentin? Common side effects of gabapentin include: Feeling tired. Dizziness. Headache. Nausea and vomiting. Fever. Difficulty speaking. Recurring infections. Memory loss. Weight gain. Movement problems: coordination problems, being unsteady, tremors, jerky movements. Cyclobenzaprine vs. Gabapentin—Important Disclaimers. While both medications are effective in treating certain conditions, there are a few key things to keep in mind: Both gabapentin and cyclobenzaprine can interact with other medications, so you must tell your doctor about all the medications you’re taking in advance to ensure your safety Taking a muscle relaxer with gabapentin can be safe when done under medical supervision. These medications may interact, leading to increased sedation, dizziness, and cognitive impairment. A Moderate Drug Interaction exists between Flexeril and gabapentin. View detailed information regarding this drug interaction. Using cyclobenzaprine together with gabapentin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. Literature Reports . A) According to the FDA Adverse Event Reporting System (FAERS) database, between January 1, 2012 and October 26, 2017, 49 cases of respiratory depression occurred with gabapentinoids (gabapentin n=15; pregabalin n=34). Using cyclobenzaprine together with gabapentin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. The following applies to the ingredients: Cyclobenzaprine (found in Flexeril) and Gabapentin MONITOR: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients. Drug interactions are reported among people who take Gabapentin (gabapentin) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include depression among females and anxiety among males. If you are taking gabapentin and Flexeril on the same day, how you do so is up to you and your doctor. You can take them at the same time, but be cautious of potential additive side effects (such as sedation). You could also separate their intake by a few hours. Flexeril (cyclobenzaprine) and Neurontin (gabapentin) have a moderate drug-drug interaction. Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients. Tramadol (ConZip, Qdolo) is an opioid medication used to treat pain. It has many possible drug interactions. Examples include gabapentin (Neurontin), cyclobenzaprine (Flexeril), and alcohol. Sertraline (Zoloft), trazodone, and tizanidine are other common culprits. Some tramadol interactions raise the risk of side effects from tramadol. Flexeril can interact with alcohol, opioids, and other central nervous system depressants, enhancing their effects and increasing the risk of respiratory depression. Gabapentin can interact with antacids, opioids, and other medications that depress the central nervous system, causing increased sedation and drowsiness. Taking Flexeril (cyclobenzaprine) and gabapentin together may result in an increase in CNS side effects like drowsiness, respiratory depression, confusion, balance problems or weakness. When a medication works right, it boosts your health or helps you feel better. But a drug can bring on problems if it doesn't mix well with something else you put into your body, like another
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