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Research has shown that gabapentin can have varying effects on individuals with depression. Some studies suggest that gabapentin may help alleviate depressive symptoms in certain cases, while others indicate that it may not have a significant impact on mood disorders. In addition to being used to treat pain, gabapentin is used off label to treat anxiety, alcohol use disorder (AUD), alcohol withdrawal, depression, substance use disorders (SUDs), sleep problems, and more. However, the data to support these off-label uses of gabapentin are mixed, especially for long-term use. While studies don’t typically show effectiveness for improving symptoms of depression, there is evidence that gabapentin may have some benefit for anxiety disorders. A rat study found that gabapentin produced behavioral changes suggestive of anxiolysis, or feelings of calmness. If someone who is using gabapentin experiences new or worsening depression as a side effect, it may be best for them to stop using the medication. However, people should not stop taking gabapentin suddenly. IMS Health data, Gabapentin dispensed prescriptions, in millions[]While it may be legal for medical practitioners to prescribe medications for off-label uses, in the United States it is illegal for manufacturers to market medications for off-label uses, which is one reason why Pfizer was fined $420 million after it was acquired from Warner-Lambert.[] Gabapentin has clearer efficacy for alcohol craving and withdrawal symptoms and may have a role in adjunctive treatment of opioid dependence. There is no clear evidence for gabapentin therapy in depression, PTSD prevention, OCD, or other types of substance abuse. Overall, while Gabapentin can be highly beneficial in treating various conditions, it must be used responsibly and under the guidance of a healthcare professional to minimize potential risks and adverse effects. In the context of the question, "can Gabapentin cause depression?", there is no direct evidence linking Gabapentin to depression. Evidence does not support the use of gabapentin for bipolar disorder, major depressive disorder (MDD), posttraumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), stimulant use disorder, or opioid withdrawal. Gabapentin isn’t usually used to treat anxiety alone. More often, it’s given to ease anxiety symptoms for someone who also has depression or bipolar disorder. (Anxiety is commonly Research has shown mixed findings regarding the impact of gabapentin on depression. Some studies have reported a higher incidence of depression among individuals taking gabapentin, while others have found no significant association. Gabapentin has less likely benefit adjunctively for bipolar disorder. Gabapentin has clearer efficacy for alcohol craving and withdrawal symptoms and may have a role in adjunctive treatment of opioid dependence. There is no clear evidence for gabapentin therapy in depression, PTSD prevention, OCD, or other types of substance abuse. Gabapentin is primarily an anticonvulsant medication, yet its association with psychiatric side effects, including depression, has garnered attention. While classified as serious but uncommon, reports indicate that depression can be exacerbated in individuals with a history of psychological issues. In 2019, the FDA added a warning and precaution about the possibility of respiratory depression that states: “There is evidence from case reports, human studies, and animal studies associating gabapentin with serious, life-threatening, or fatal respiratory depression when coadministered with CNS depressants, including opioids, or in the A Mayo Clinic research group published a case-control study describing the relationship between preoperative gabapentin exposure and the risk of postoperative respiratory depression in more than Gabapentin can affect mood and may cause depressive symptoms, though this is considered a rare side effect. While it is primarily used to treat seizures and nerve pain, some individuals have reported experiencing feelings of sadness or worsening depression during treatment. Gabapentin has less likely benefit adjunctively for bipolar disorder. Gabapentin has clearer efficacy for alcohol craving and withdrawal symptoms and may have a role in adjunctive treatment of opioid dependence. There is no clear evidence for gabapentin therapy in depression, PTSD prevention, OCD, or other types of substance abuse. But wait, there’s more! Depression and suicidal thoughts can also make an unwelcome appearance. It’s as if gabapentin decided to invite the gloomiest rain cloud to your mental picnic. These feelings can range from a persistent low mood to more severe depressive symptoms. In some cases, patients may experience thoughts of self-harm or suicide. Similar to other anticonvulsant medicines, gabapentin may increase the risk of depression and suicidal thoughts, particularly in young adults under the age of 24. Gabapentin has been associated with a discontinuation syndrome when abruptly stopped. Symptoms include anxiety, insomnia, nausea, pain, and sweating. Gabapentin (Neurontin) is FDA approved to treat seizure disorder and nerve pain from shingles. But it’s also used off-label to treat many other conditions, including anxiety, nerve pain from diabetes, and hot flashes. Gabapentin may be effective for anxiety, but it’s usually not a first-choice medication for this use. This article presents the negative side effects of gabapentin such as psychotic and depressive symptoms, which occur shortly after its use. The use of gabapentin in mood disorders is discussed through these side effects. Keywords: Gabapentin; depression; psychosis; side effects. © The Author (s) 2015.
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