The use of gabapentin tablets in patients less than 12 years of age with compromised renal function has not been studied. 2.4 Dosage in Elderly. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and dose should be adjusted based on creatinine clearance values in these patients. Gabapentin is approved to prevent and control partial seizures, relieve postherpetic neuralgia after shingles and moderate-to-severe restless legs syndrome. Learn what side effects to watch for, drugs to avoid while taking gabapentin, how to take gabapentin and other important questions and answers. 8 USE IN SPECIFIC POPULATIONS . 8.1 Pregnancy . 8.2 Lactation 8.4 Pediatric Use . 8.5 Geriatric Use 8.6 Renal Impairment . 9 DRUG ABUSE AND DEPENDENCE . 9.1 Controlled Substance . 9.2 Abuse 9.3 Dependence . 10 OVERDOSAGE 11 DESCRIPTION 12 CLINICAL PHARMACOLOGY . 12.1 . Mechanism of Action 12.3 . Pharmacokinetics . 13 NONCLINICAL TOXICOLOGY The median single dose for gabapentin abuse is 3600 mg, which is 3 times the maximum recommended single dose of 1200 mg. 12 Risk factors for gabapentin abuse include current or previous opioid abuse, previous cocaine use, and/or concurrent use of benzodiazepines or cannabis. Detailed Gabapentin dosage information for adults and children. Includes dosages for Restless Legs Syndrome, Epilepsy and Postherpetic Neuralgia; plus renal, liver and dialysis adjustments. The use of gabapentin in patients less than 12 years of age with compromised renal function has not been studied. 2.4 Dosage in Elderly. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and dose should be adjusted based on creatinine clearance values in these patients. Adults— At first, 300 milligrams (mg) as a single dose in the evening. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 1800 mg per day. Children—Use and dose must be determined by your doctor. GABAPENTIN (GA ba pen tin) treats nerve pain. It may also be used to prevent and control seizures in people with epilepsy. It works by calming overactive nerves in your body. Gabapentin extended-release tablets (Horizant) are used to treat restless legs syndrome (RLS; a condition that causes discomfort in the legs and a strong urge to move the legs, especially at night and when sitting or lying down). Gabapentin is in a class of medications called anticonvulsants. In a single (400 mg) and multiple dose (400 mg three times a day) study of gabapentin in epileptic patients (N = 8) maintained on phenytoin monotherapy for at least 2 months, gabapentin had no effect on the steady-state trough plasma concentrations of phenytoin and phenytoin had no effect on gabapentin pharmacokinetics. In a single (400 mg) and multiple dose (400 mg three times a day) study of gabapentin in epileptic patients (N=8) maintained on phenytoin monotherapy for at least 2 months, gabapentin had no effect on the steady-state trough plasma concentrations of phenytoin and phenytoin had no effect on gabapentin pharmacokinetics. Gabapentin (Neurontin, Gralise, Horizant) is a medicine used to treat partial seizures, nerve pain from shingles and restless leg syndrome. It works on the chemical messengers in your brain and nerves. Gabapentin is from a group of medicines called anticonvulsants. Gabapentin can be removed from plasma by hemodialysis. Special Populations Adult Patients With Renal Insufficiency Subjects (N=60) with renal insufficiency (mean creatinine clearance ranging from 13 to 114 mL/min) were administered single 400 mg oral doses of gabapentin. The mean gabapentin half-life ranged from about 6.5 hours (patients with Gabapentin is used to control seizures, to treat nerve pain that can happen after having had shingles, and to treat a condition called restless legs syndrome. In addition to these FDA-approved uses, doctors sometimes prescribe gabapentin off-label. Single dose oral gabapentin for established acute postoperative pain in adults. Cochrane Database of Systematic Reviews 2010, Issue 5. Art. No.: CD008183. DOI: 10. The typical starting dosage of gabapentin for seizures is 300 mg by mouth three times a day, with or without food. Your prescriber may adjust your gabapentin dosage to up to 600 mg 3 times a day (1,800 mg per day). The maximum gabapentin dosage is 3,600 mg per day, but higher doses are more likely to cause side effects.Restless legs syndrome In a single (400 mg) and multiple dose (400 mg three times a day) study of GABARONE in epileptic patients (N=8) maintained on phenytoin monotherapy for at least 2 months, gabapentin had no effect on the steady-state trough plasma concentrations of phenytoin and phenytoin had no effect on gabapentin pharmacokinetics. In a single (400 mg) and multiple dose (400 mg three times a day) study of gabapentin in epileptic patients (N=8) maintained on phenytoin monotherapy for at least 2 months, gabapentin had no effect on the steady-state trough plasma concentrations of phenytoin and phenytoin had no effect on gabapentin pharmacokinetics. Data from meta-analyses support the use of IR gabapentin for reducing pain by more than 50% in diabetic neuropathy Moore 2014, Rudroju 2013. Data from a limited number of clinical trials support the use of ER gabapentin in reducing pain by more than 50% and improving sleep in diabetic neuropathy Sandercock 2009, Sandercock 2012. Gabapentin is commonly used to treat and prevent seizures in people with epilepsy or to treat nerve pain (postherpetic neuralgia) that can occur after a viral infection called shingles.
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