What non-hormonal medicines are used to reduce hot flushes? The non-hormonal medicines used to reduce hot flushes in women include gabapentin, clonidine, venlafaxine or selective serotonin reuptake inhibitors (SSRIs). The treatment option depends on the individual. Gabapentin Brand name: Neurontin® available as 100mg, 300mg and 400mg capsules. Objective: Gabapentin is used to treat vasomotor symptoms (VMS) in postmenopausal women with contraindications to hormonal therapy or who prefer alternatives. We investigated the efficacy and tolerability of gabapentin for treating menopausal hot flushes via a meta-analysis. The Food and Drug Administration (FDA) has not approved the official use of gabapentin for hot flashes. However, clinical studies show it can be effective in reducing their earched the PubMed, MEDLINE, EMBASE, and CENTRAL databases for English-language articles published until June, 2018. The following search terms were used: “menopause,” “hot flushes,” “vasomotor symptoms,” “gabapentin,” and “non-hormonal therapy.” Primary outcomes were frequency, duration, and composite score of hot flushes. Secondary outcomes were adverse effects and Other agents that have been used to alleviate hot flashes include belladonna/ergotamine tartrate/phenobarbital combination, dong quai, evening primrose oil, gabapentin, ginseng, mirtazapine Other antidepressants that have been used to treat hot flashes include: Venlafaxine (Effexor Xr). Paroxetine (Paxil). Gabapentin (Neurontin, Gralise, others). Fortunately, a new treatment option may be able to treat hot flashes without the risk. Gabapentin, an anticonvulsant, may be effective for the treatment of hot flashes. Often sold as Neurontin, gabapentin is approved by the Food and Drug Administration (FDA) for the treatment of epilepsy. How Gabapentin Helps with Hot Flashes. Gabapentin has shown promising results in reducing both the frequency and severity of hot flashes. The exact mechanism by which Gabapentin alleviates hot flashes is not entirely understood, but several theories exist. Scientific Studies and Findings Gabapentin is effective in the control of hot flashes at a dose of 900 mg/day, but not at a dose of 300 mg/day. This drug should be considered for treatment of hot flashes in women with breast cancer. Gabapentin 300 mg/day could be useful to relieve hot flashes in women for whom hormone therapy is not suitable or when hot flashes do not respond to other therapies. Further researches are needed to determine the efficacy of gabapentin use for longer periods or at higher doses. Gabapentin is usually used to control epilepsy or chronic nerve (neuropathic) pain. It is also a non-hormonal medicine that has been shown to be effective in reducing menopausal hot flushes. Gabapentin appears to be comparable with low dose oestrogen in reducing the frequency and severity of hot flushes.3 What is the usual dosage? You will hot flushes. Gabapentin in higher doses has been shown to be as effective as estrogen in reducing the severity and frequency of hot flushes. Before you take gabapentin Tell your doctor if you are taking other medications, herbal products or consuming alcohol, in particular: • Antacids – medicines used to treat heartburn
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