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There is no evidence to show that gabapentin has a large positive effect in the treatment of tinnitus[2]. One study showed treatment with gabapentin led to an increase in tinnitus[3]. A different study showed no differences on the Tinnitus Handicap Inventory compared to placebo[4]. We found that gabapentin significantly decreased the VAS score in patients with tinnitus due to acoustic trauma. Moreover, gabapentin significantly increased the frequency of patients responding to treatment (≥30% decrease in VAS). The authors of both studies reported that gabapentin was not superior to placebo in their primary outcomes. However, following the assessment of risk of bias and within-study clinical heterogeneities, this review concludes that there is insufficient evidence regarding the effect of gabapentin on tinnitus. Arguably, one of the drugs that has been studied most extensively as a tinnitus treatment is gabapentin (marketed as Neurontin®). It is useful to look at the history of this drug to appreciate the promise and pitfalls encountered when searching for effective tinnitus treatments. The pharmacologic management of tinnitus with brain-acting effects (for example, amitriptyline, acamprosate, and gabapentin) and those with anti-inflammation/anti-oxidant effect (for example, intra-tympanic dexamethasone injection plus oral melatonin) appear to serve as the preferable effective treatments for tinnitus without specific or Gabapentin for Tinnitus: A Systematic Review. Link (Accessed 1/7/19) Ototoxicity: The Hidden Menace. PubMed (Accessed 1/7/19) A probable case of gabapentin-related reversible hearing loss in a patient with acute renal failure. PubMed (Accessed 1/7/19) Effect of gabapentin on the sensation and impact of tinnitus. PubMed (Accessed 1/7/19) Gabapentin forthe treatment of tinnitus: A case report John Joseph Zapp, MD Abstract The objective ofthis article is to discuss the clinically effective use ofgabapentin in patients with tinnitus. The author describes the case ofa man who came to the office complaining of tinnitus of 10 months' duration. The The clinical trial of gabapentin was funded by the Tinnitus Research Consortium. We are grateful to Luisa Ciobanu, Ph.D., Biomedical Imaging Center, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, for her expertise and assistance in obtaining the GABA spectra, and Kristin Myers, for her But Gabapentin (Neurontin) has far more reports of ototoxic side effects such as hearing loss and tinnitus than Paclitaxel, so it is more likely that you are correct in assuming that the Neurontin is the culprit causing your hearing loss. Calcium channel modulation. Gabapentin is thought to function as a GABA-modulator and alpha-2-delta calcium channel antagonist – and modulation of calcium channels may be its primary mechanism in the treatment of select cases of tinnitus. Despite these positive findings, several large, randomized clinical trials found that gabapentin was not significantly different from placebo in treating tinnitus, with the possible exception that it reduced tinnitus annoyance in a subgroup of patients with noise-induced tinnitus (186–189). The overall trend that has emerged from randomized Tinnitus can be a chronic symptom that brings disability and distress. Some studies suggested that gabapentin might be effective on tinnitus relief. The objective of the study is to perform a systematic review in order to evaluate the efficacy of oral gabapentin in patients with tinnitus. I have tinnitus and just saw my ENT and he said gabapentin was not a med that should cause it. However I have had to stop the pain meds Tylenol, NSAIDs and similar, and I had a bad tinnitus reaction at one point to Pepto-Bismol, which is a salicylate like aspirin. months, and their tinnitus must have been nonpulsatile, subjective, and idiopathic. Exclusion criteria included pregnancy, current breastfeeding, the presence of any curable etiology for the tinnitus, bilateral tinnitus, contraindications to gabapentin use, and the consump-tion of any drugs that might interact with gabapentin or cause tinnitus. Gabapentin is effective in reducing subjective and objective aspects of tinnitus in some individuals, with the best therapeutic response obtained in individuals with associated acoustic trauma. There have been numerous studies that examine the efficacy of Neurontin as a treatment of tinnitus. While there has been some consensus that it is no better than a placebo, a recent meta-study suggests that no firm conclusions can be drawn:
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