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Although all patients with IBS have symptoms of abdominal pain and disordered defecation, treatment needs to be individualized and should focus on the predominant symptom. This paper will review therapeutic options for the treatment of IBS using a tailored approach based on the predominant symptom. Our results show that gabapentin reduces rectal sensory thresholds through attenuating rectal sensitivity to distension and enhancing rectal compliance in diarrhoea-predominant irritable bowel syndrome patients. Yes, Gabapentin can be used for the treatment of Irritable Bowel Syndrome (IBS). Many researchers have monitored the effects of gabapentin in the management of IBS and have observed positive results. What does research suggest? Drugs that effectively manage neuropathic pain disorders (gabapentin and pregabalin) reportedly improved global IBS symptoms and alleviated visceral pain, which requires further confirmation. Clonidine appears to be the only conventional pain-managing drug that benefits the general IBS population. Gabapentin, a 3-alkylated analogue of γ-amino butyric acid (GABA), has recently been used for the treatment of neuropathic pain with minimal side-effects. 7 Gbapentin has been shown to attenuate hyperalgesia and allodynia in animal models of neuropathic, inflammatory and surgical pain. 8–13 Although its mechanism of action remains unclear Abdominal pain is a common symptom in patients with inflammatory bowel disease (IBD) and has a profound negative impact on patients’ lives. There are growing data suggesting that pain is variably related to the degree of active inflammation. Given Pain is a common complaint among patients with inflammatory bowel disease (IBD). 1 – 3 Pain is a component of several disease activity indices, and it is one of the principal concerns for patients. 4, 5 Pain is a common reason for the poor quality of life (QOL) often seen in patients with IBD. 2, 6, 7 Also, the uncontrollable aspects of pain are associated with profound anxiety. I started recently on Gabapentin to treat abdominal distension and pain from IBS-C. The doctor started me on a very low dose (50 mg), and now that I've been on it for 2 weeks, I'm increasing to 100 mg. Gabapentin is a gamma-aminobutyric acid (GABA) analog that is initially developed for treating epilepsy but is currently used for various cases, including pain relief, and in particular neuropathic pain (such as headache and back pain). [4] . These criteria include belly pain and discomfort averaging at least one day a week in the last three months. This also usually occurs with at least two of the following: pain and discomfort related to defecation, a change in the frequency of defecation, or a change in stool consistency. Type of IBS. Anti-neuropathic analgesics may improve pain in IBS, and deserve further, high-quality investigation, potentially considering parenteral administration and agents with minimal gastrointestinal motility effects. The Visceral Sensitivity Index has been validated for measuring the severity of pain in IBS. The McGill Pain Questionnaire is also not specific for abdominal pain but provides information about pain intensity and also a qualitative description of the pain (eg, burning vs stabbing). General pain intensity scales, such as the Visual Analog Scale Clonidine, gabapentin and pregabalin can moderately improve IBS symptoms. Lubiprostone relieves constipation predominant IBS (IBS-C) while loperamide improves diarrhea predominant IBS (IBS-D). Neurotransmitter dysfunctions are related to some gastrointestinal IBS symptoms. Visceral hypersensitivity has been correlated to decreased glutamine levels, lower levels of GABA in the anterior cingulate cortex, higher levels of 5-hydroxy-indol acetic acid, increased expression of high affinity choline transporter, downregulation of α-2 adrenoceptors, augmented sensitivity of central However, like in many chronic pain conditions, prolonged visceral pain in IBS is initiated by activities in peripheral sensory (afferent) neurons ( 4, 18, 19 ). This is readily supported by simple clinical and preclinical experiments of blocking afferent input into the CNS. Gabapentin is a medication that has been shown to be effective in treating Irritable Bowel Syndrome (IBS) by reducing rectal mechanosensitivity and increasing rectal compliance. It is also used to relieve painful bowel spasms and treat diarrhea.
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