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Neurontin - also known as Gabapentin - is a drug that is sometimes prescribed to those who experience anxiety especially in situations where the anxiety is co-occurring with bipolar disorder. This article explores the usage of Neurontin, as well as the benefits, weaknesses, and side effects for those looking to learn more about this medication Gabapentin may be a useful drug for the add-on treatment of bipolar patients with poor response to other mood stabilizers. Gabapentin may improve depressive residual symptoms such as irritability, social withdrawal or anxiety. These results should be confirmed in randomized clinical trials. Other medications, like topiramate (Topamax) or gabapentin (Neurontin), may be prescribed in some cases when other treatments haven’t worked. Right now, there is no good evidence that gabapentin can be used for treating people with bipolar disorder. High-quality, randomized controlled studies found that Gabapentin for Bipolar Disorder User Reviews Brand names: Neurontin, Gralise, Gabarone, Fanatrex Gabapentin has an average rating of 8.5 out of 10 from a total of 138 reviews for the off-label treatment of Bipolar Disorder. other parts of the bipolar spectrum (bipolar disorder, type II, and bipolar disorder, NOS; 11/27, 41%) was over twice that of bipolar disorder type I (2/13, 15%, p = .16, Fisher’s exact test) or unipolar major depressive disorder (2/10, 20%, p = .44, Fisher’s exact test), but these differ-ences were not statistically significant. Despite of the lack of evidence, reviews of gabapentin prescribing patterns in the United States show that this medication is still being used with alarming frequency for bipolar disorder. There are now five medications with specific, FDA approval for acute bipolar depression. The gabapentinoids, gabapentin, and pregabalin, target the α<sub>2</sub>δ subunits of voltage-gated calcium channels. Initially licensed for pain and seizures, they have become widely prescribed drugs. Many of these uses are off-label for psychiatric indications, and there is increasing concern abou A systematic search strategy employing different combinations of the keywords (bipolar, mania, hypomania, gabapentin, neurontin, gralise, gabarone, fanatrex, pregabalin, lyrica) was developed and performed in five databases namely OVID Medline, PubMed, ProQuest, PsychInfo and ScienceDirect from database inception to 7 June 2021. The use of gabapentin in bipolar disorder (BPD) treatment provides an informative case of off-label uptake and abandonment of a new medication. Gabapentin was patented by Warner-Lambert in 1977 and FDA-approved in December1993 for the adjunctive treatment of epilepsy and in 2002 for postherpetic neuralgia (see Appendix 1 for timeline). Researchers found that gabapentin does not help people with bipolar disorder. Learn more about the history of why some doctors prescribe gabapentin for bipolar as an adjunct therapy, even though there’s no evidence that it works for bipolar treatment or maintenance. Neurontin is sometimes prescribed off-label for the treatment of the following conditions: Bipolar disorder: Bipolar disorder is a mental condition that causes sudden and extreme changes, in mood, energy levels, and daily functioning. These moods can range from irritable and sad to happy and energetic with no warning. The results suggest that gabapentin may be of benefit to bipolar patients who only partially respond to other mood stabilizers. A favorable side-effect profile and rapid action make this drug an attractive choice as an adjunctive therapy. Background: Gabapentin, a new anti-epileptic agent, has been anecdotally reported to be effective in the treatment of mania. We systematically assessed the response rate in bipolar patients being treated adjunctively with gabapentin for manic symptoms, depressive symptoms, or rapid cycling not responsive to standard treatments. Lithium and gabapentin. Gabapentin is currently being studied as a treatment for bipolar disorder, and there have been favorable reports regarding its potential as a mood stabilizer (82, 83). The advantages of gabapentin include the lack of interactions with other drugs in the cytochrome P450 system and the lack of protein binding . Since there The roles of lamotrigine and gabapentin in the treatment of bipolar disorder (either as monotherapy or as supplemental agents) have as yet to be clarified. Lamotrigine may be of particular benefit in bipolar depression. While gabapentin is frequently used in practice for a wide array of psychiatric diagnoses, its use is evidence-based for only a few indications. Multiple RCTs have shown gabapentin to be ineffective for bipolar disorder. There is insufficient evidence to recommend the use of gabapentin for MDD, GAD, PTSD, or OCD. For bipolar disorder, four double-blind RCTs investigating gabapentin, and no double-blind RCTs investigating pregabalin, were identified. A quantitative synthesis could not be performed due to Issue: Most patients with a bipolar spectrum disorder are treated with 2 or more drugs in combinations that are sometimes rational and evidence-based and sometimes not. a hot topic, with many new agents now available and many new combinations being touted. On the basis of the Clinical Global Impressions Scale for Bipolar Illness (CGI-BP), lamotrigine was superior in reducing symptoms versus gabapentin and placebo. 20 Obrocea et al 21 also found gabapentin and placebo inferior to lamotrigine in a crossover study of 35 patients with bipolar disorder and 10 patients with unipolar disorder for
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