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Objectives: The purpose of this study was to assess serum concentrations of gabapentin in cats with chronic kidney disease (CKD) vs clinically healthy cats. Methods: Five healthy cats were enrolled in a pharmacokinetic study. A single 20 mg/kg dose of gabapentin was administered orally and blood was obtained at 0, 0.25, 0.5, 1, 1.5, 2, 3, 4, 8 1. Is gabapentin safe for cats with kidney disease? Yes, gabapentin is considered safe for use in cats with kidney disease when dosed appropriately and monitored closely by a veterinarian. 2. Will gabapentin interact with other medications my cat is taking? The cats with CKD were of different breeds and either in stage 2 or stage 3 of kidney failure. The research team measured gabapentin, symmetric dimethylarginine (SDMA), and creatinine concentration levels in the blood (serum) at three hours and eight hours after medication was given. Gabapentin is often prescribed in lower amounts for patients with kidney disease because the drug levels could rise if the renal system does not clear it out properly. One reason for renal failure or renal scarcity is kidney disease. This begs the question as to why doctors would risk diseased cats with higher doses. Investigating appropriate dosing for gabapentin sedation in cats with and without chronic kidney disease (2017) Winn Feline Foundation reports on the study's goals and Gabapentin sedation in cats with and without chronic kidney disease (2020) Winn Feline Foundation gives an update, stating that CKD cats seem to have much higher levels of Investigating appropriate dosing for gabapentin sedation in cats with and without chronic kidney disease (2017) Winn Feline Foundation reports on the study's goals and Gabapentin sedation in cats with and without chronic kidney disease (2020) Winn Feline Foundation gives an update, stating that CKD cats seem to have much higher levels of MT17-002: Investigating appropriate dosing for gabapentin sedation in cats with and without chronic kidney disease. (An EveryCat-funded grant project, final published report) (An EveryCat-funded grant project, final published report) What is the recommended gabapentin dosage for cats with kidney disease? While the standard dosage for healthy cats is 20mg/kg, cats with chronic kidney disease (CKD) should be given a reduced dose of 10mg/kg. Sixteen chronic kidney disease (CKD cats) – (ten IRIS Stage 2, twelve IRIS Stage 3) – have completed the limited sampling PK study at 10 mg/kg. Samples from eight CKD cats have been analyzed to date to test the model. The model performed well and the data for normal cats demonstrated that half-life was similar to previous published reports. Gabapentin may decrease arterial BP in cats with and without CKD and these findings should be taken into account when gabapentin is administered to patients in which measurement of BP is needed. Visits to the veterinary clinic can be a source of stress for both the feline patient and the caregiver. My 15 year old cat has renal disease & heart failure & has 2.5mg benazepril each night & 20mg frusemide three times/day. He now has some pain in his back legs & possibly his hips & my vet has given me some 100mg capsules of gabapentin. What dose should we use, and can we use this daily in cats? What about in cats with chronic kidney failure? In this podcast, we discuss if transdermal gabapentin can be safely used in cats, and how to administer dose this capsule. The 20 mg/kg stress-reduction dose of gabapentin may be beneficial to facilitate preventive veterinary care in younger, healthy cats, but this dose may be inappropriate for elderly cats, specifically those with chronic kidney disease (CKD). Gabapentin is not metabolized or protein bound, and is cleared only by renal excretion in humans; it is unknown whether this is also true in cats. 7 In humans, it has been demonstrated that kidney disease significantly influences the pharmacokinetics (PK) of gabapentin, and a 60% and 85% decrease in gabapentin clearance is seen in moderate and Gabapentin is not known to directly cause kidney failure in cats. The drug is primarily cleared through the kidneys, but it does not usually cause kidney damage. In rare cases, DRESS syndrome, which can affect the kidneys, has been linked to gabapentin. Higher doses of gabapentin can be problematic for cats with chronic kidney disease. A 50% dose reduction or more is typically recommended. Your vet should adjust the dosage accordingly if kidney disease is present. kidney disease (CKD). Gabapentin is not metabolized or protein bound, and is cleared only by renal excretion in humans; it is unknown whether this is also true in cats.7 In humans, it has been demonstrated that kidney dis-ease significantly influences the pharmacokinetics (PK) of gabapentin, and a 60% and 85% decrease in gabapentin The question of whether gabapentin is safe for cats with chronic kidney disease (CKD) is complex and requires careful consideration. The short answer is: it can be safe when used judiciously, but it’s not without risks and requires dosage adjustments due to the kidneys’ role in its elimination. The question of whether gabapentin is harmful for cats with kidney disease is complex and doesn’t have a simple yes or no answer. While gabapentin isn’t inherently nephrotoxic (toxic to kidneys), its use in cats with pre-existing kidney issues requires careful consideration and monitoring. Cats with chronic kidney disease (CKD) exhibit higher serum concentrations of gabapentin, indicating a need for dose adjustment. It’s essential to administer lower doses to avoid potential toxicity and monitor their response closely.
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