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I have swelling in my legs caused by lymphedema and have to wear compression socks but mine was not caused by a medication. I also would be concerned if it's been over 5 months since stopping gabapentin and the swelling and pain is still in the hands and feet. Amlodipine (Norvasc), gabapentin (Neurontin, Horizant, Gralise), and pregabalin (Lyrica) can cause puffy legs and ankles. Birth control pills, certain over-the-counter pain medications, and steroids are a few other culprits. He noticed significant leg swelling almost immediately upon starting treatment; this persisted for nearly three weeks before gradually improving after his doctor reduced his dosage. These cases highlight how individual responses vary widely based on dosage levels and personal health backgrounds while using gabapentin. It is important to recognize this adverse effect because gabapentin is used in conditions like diabetic neuropathy, which is associated with multiple co-morbidities that can give rise to bilateral leg swelling. Presence of gabapentin induced leg swelling can thus confound the clinical picture. Keywords: Edema, gabapentin, lower extremity It is important to recognize this adverse effect because gabapentin is used in conditions like diabetic neuropathy, which is associated with multiple co-morbidities that can give rise to bilateral leg swelling. Presence of gabapentin induced leg swelling can thus confound the clinical picture. Key words: Edema, gabapentin, lower extremity One of the key symptoms of edema is noticeable swelling in specific areas of the body, such as the feet, ankles, legs, or hands. This swelling may be accompanied by tightness or a feeling of heaviness in the affected areas. Additionally, individuals may experience discomfort, pain, or difficulty moving due to the increased fluid retention. Gabapentin is a medication that treats nerve pain by calming overactive nerves in your body. It may also prevent and control seizures in people with epilepsy. You can take this medication by mouth with a glass of water. Furthermore, experimental data have shown an indirect inhibitory effect of gabapentinoids (ie, gabapentin, pregabalin) on the Cav1.2 channel pore of arterial myocytes, leading to vasodilatory effects and inhibition of the myogenic tone. 96-98 These data suggest that gabapentinoid-related peripheral edema 94, 95 may exhibit the same 4 Answers - Posted in: fluid retention, gabapentin, drug - Answer: Yes,. Swelling will go away after using for awhile. My feet were swollen This is a case of painful, 4+ pitting bilateral edema with a probable association to gabapentin (Naranjo score 5) and a clear dose relationship in a patient with pervasive developmental disorder and schizoaffective disorder utilizing gabapentin for mood stabilization. Gabapentin is a common medication-related cause of peripheral edema. This is when you experience swollen tissues in the body, often in the arms and legs. Up to 8% of people report edema with gabapentin clinical studies. But it’s more likely to occur in older adults. It’s also more likely with higher gabapentin dosages (greater than 1,800 mg). Fluid retention, or edema, can occur when gabapentin affects vascular permeability or alters kidney function. Edema refers to swelling caused by excess fluid accumulation in tissues. It can occur in various parts of the body but is most commonly seen in the legs, ankles, and feet. The gabapentin did help my neuropathy, and I was able to come off the pain medication, but it came with a variety of other new horrifying side effects. I struggled with my short-term memory, terrible confusion and lack of energy due to the gabapentin. I was on 1000mg of Gabapentin 3 times daily (3000mg total per day) for two years. I take 600 mg of gabapentin, 300 mg twice daily. No swelling in my feet. I still get some cramping and stabbing. I hope everything is going well with others. Some side effects of gabapentin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. It is important to recognize this adverse effect because gabapentin is used in conditions like diabetic neuropathy, which is associated with multiple co-morbidities that can give rise to bilateral leg swelling. Presence of gabapentin induced leg swelling can thus confound the clinical picture. Keywords. Edema, gabapentin, lower extremity Background. Gabapentin binds to the alpha-2-delta subunit of presynaptic voltage-gated calcium channels and is used for a wide variety of indications both Food and Drug Administration approved and off-label. 1-3 It is approved by the Food and Drug Administration to treat postherpetic neuralgia and epilepsy 4 with common off-label indications including fibromyalgia, anxiety, mood disorders, and This case illustrates that gabapentin induced leg swelling can confound the clinical picture and it is thus important to recognize this side effect of gabapentin. CONCLUSIONS: Due to extensive etiologies of peripheral edema, medications can often be overlooked subjecting the patients to unnecessary testing and treatment. Edema is a well-described side effect of gabapentinoid drugs (i.e., gabapentin and pregabalin). In this study from Ontario, Canada, researchers used provincial databases to examine whether gabapentinoid use was followed by diuretic prescriptions — a so-called “prescribing cascade” in which a drug is prescribed to treat an adverse effect of another drug. Gabapentin binds to the alpha-2-delta subunit of presynaptic voltage-gated calcium channels and is used for a wide variety of on- and off-label indications. Gabapentin is dosed at total daily doses ranging from 300 to 3600 mg/d, which is generally divided into 3 doses. Although gabapentin is general
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